Anone follows the story of Harika Tsujisawa, a young woman who has been abandoned by her family and lives a solitary life working at a net cafe. Her path crosses with an elderly woman named Toko Hayashida, who runs a printing shop and has also been isolated from society. As they form an unlikely bond, they encounter other individuals living on the fringes of society, including a mysterious girl who has been abandoned by her parents. The series explores themes of loneliness, the definition of family, and the search for human connection in a cold, indifferent world. As the characters navigate their shared trauma and secrets, they begin to construct a makeshift family, challenging societal norms and finding solace in their collective struggle to survive and find meaning in their existence.