Midnight Museum follows Dome, a young man who lands a job at a mysterious, strange museum that only opens at night. The museum is run by Khatha, a man who possesses supernatural abilities and manages a collection of cursed, haunted, and magical artifacts. As Dome begins his work, he discovers that the museum is not merely a place for display, but a repository for dangerous items that hold dark secrets and tragic histories. As Dome delves deeper into the museum's operations, he becomes entangled in a series of supernatural events and investigations. Alongside Khatha and a team of eccentric individuals, he must navigate the thin line between reality and the paranormal. The series explores themes of greed, obsession, and the consequences of holding onto the past, as the characters face off against entities and individuals seeking to exploit the museum's powerful collection.