Run On follows the life of Ki Seon-gyeom, a former track and field athlete who decides to retire after feeling unable to be himself in the sport. His path crosses with Oh Mi-joo, a passionate and hardworking subtitle translator for films who views the world through a different lens. As they navigate their personal struggles and professional lives, they begin to bridge the gap between their disparate worlds through honest communication and mutual support. The series also explores the complex relationship between Seo Dan-ah, a driven and ambitious sports agency CEO, and Lee Young-hwa, a talented art student who challenges her guarded exterior. Together, the four protagonists navigate the intricacies of love, career ambitions, and the importance of finding one's own voice, ultimately learning that connection requires both patience and the courage to 'run on' despite life's obstacles.