Set in a fictional, economically depressed county called Muji-gun, 'Save Me' follows Im Sang-mi and her family after her father's failed business forces them to move from Seoul. Isolated and vulnerable, the family falls prey to Goseongwon, a sinister religious cult led by the charismatic and manipulative Spiritual Father Baek Jung-ki. Years later, after her twin brother commits suicide due to relentless bullying and her mother loses her mind, Sang-mi desperately whispers 'Save me' to four unemployed local youths she encounters in an alleyway. Led by Han Sang-hwan, the son of a powerful local politician, the four young men decide to take action and rescue Sang-mi from the clutches of the cult. As they delve deeper into Goseongwon, they uncover a terrifying web of corruption, human trafficking, and psychological abuse. The series becomes a harrowing psychological thriller and survival drama as the youths risk everything to expose the cult and free Sang-mi.