Alice follows the story of Park Jin-gyeom, a detective born with a condition that makes him emotionless, who discovers the existence of time travelers while investigating a mysterious case. These travelers arrive from the future through a space-time portal known as 'Alice'. As Jin-gyeom delves deeper into the truth, he encounters Yoon Tae-yi, a brilliant physicist who bears a striking resemblance to his late mother. Together, they navigate the complexities of time travel, fate, and the consequences of altering the past. As Jin-gyeom attempts to protect Tae-yi from the dangers posed by those who wish to exploit the portal, he uncovers dark secrets about his own origins and the true purpose of Alice. The series blends elements of science fiction, mystery, and emotional drama as the characters struggle to reconcile their pasts with an uncertain future.